This course covers the main topics related to comprehensive care for people with sexually transmitted infections (STIs). These topics are as follows: epidemiology of STIs in Brazil and in the Americas, epidemiological surveillance system in Brazil, surveillance of syphilis, surveillance of urethral discharge, history of syphilis, acquired syphilis, congenital syphilis, diagnostic tests for congenital syphilis investigation, syphilis in pregnancy, approach to care for the infant exposed to syphilis, neurosyphilis, diagnostic tests for syphilis investigation; Chlamydia trachomatis infection: background, epidemiology, clinical aspects, diagnosis, treatment, complications, sequelae and special populations (pregnant women, neonates, and people living with HIV); gonorrhea: background, epidemiology, clinical aspects, diagnosis, treatment, antimicrobial resistance, complications, sequelae and special populations (pregnant women, neonates, and people living with HIV); other causes of cervicitis and urethritis: Mycoplasma genitalium, Ureaplasma urealyticum and other agents, tests for differential diagnosis and multidrug resistance, complications and sequelae; vaginitis: trichomoniasis, candidiasis and special populations regnant women, neonates, and people living with HIV, in addition to other causes of vaginal discharge; herpes infection: background, epidemiology, clinical aspects, diagnosis, treatment, complications, sequelae, special populations (pregnant women, neonates, and people living with HIV); HPV infection: background, epidemiology, clinical aspects, treatment, complications, diagnosis and vaccination; HTLV Infection: background, epidemiology, clinical aspects, diagnosis, treatment, special populations (pregnant women, neonates, and indigenous peoples), complications and sequelae; welcoming process for people with STIs; management of STI cases in pregnant women; approach to STIs in victims of sexual violence; approach to STIs in people living in situations of vulnerability. Each unit is composed of a video lesson, support material, and multiple-choice evaluation questions.